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080417 Spare tire risks associated with carrying fat around your stomach. (2/2)

080417 Spare tire risks associated with carrying fat around your stomach. (2/2)

Continued from 030417

The study by doctors in Seattle also noted that insulin resistant people with excess abdominal fat also appeared to show higher concentrations of a substance known as apolipoprotein B (apoB) and lower levels of high-density lipoprotein (HDL) cholesterol, a “good” form of cholesterol. Previous studies have suggested that high levels of apoB may encourage the development of arteriosclerosis.

Study author Dr. Steven E. Kahn of the VA Puget Sound Health Care System in Seattle, Washington, states that he and his colleagues suspect that a potbelly likely precedes insulin resistance. Once both conditions have set in, he noted, people’s bodies are more likely to be primed to develop arteriosclerosis.”We think that the deposition of fat in the inside of the abdomen is the critical determinant of insulin resistance in the general population,” Kahn said. “We think that the fat begets the insulin resistance, which helps produce” risk factors for arteriosclerosis, he added.

Kahn’s is not the first study to identify health hazards of potbellies. Although body fat tends to relocate to the abdomen with age, past research has shown that excess belly fat, compared to fat elsewhere on the body, can increase the risk of heart disease and type 2 diabetes, as well as up the chances of stroke in middle age.

In the current study, Kahn and his colleagues measured body fat distribution and screened for insulin resistance in 196 people. The authors also determined how much choesterol, fat, and apoB was present in each participant’s blood.

The average age of study participants was 53. They were all seemingly healthy, with no history of diabetes or cardiovascular disease.

Reporting in the January issue of Diabetes, Kahn and his colleagues discovered that people with bigger potbellies who were more resistant to insulin also had lower levels of HDL cholesterol and higher levels of low-density lipoprotein (LDL) cholesterol–the “bad” form of cholesterol.

Risk factors for arteriosclerosis appeared to be linked more strongly to tummy size than to whether a person had insulin resistance, Kahn and his team note.

The current study findings suggest that even people who are not obese can be at risk of arteriosclerosis, the authors note. Seemingly slim people can carry excess tummy fat and be resistant to insulin, they write, and can therefore be at risk for the blood vessel disease.

In an interview, Kahn noted that abdominal fat could play an essential role in people’s risk of future disease. Specifically, he said having a pot belly “is a critical component of metabolic syndrome,” a condition marked by insulin resistance and high blood pressure, and which often precedes diabetes and cardiovascular disease. SOURCE: Diabetes 2003;52:172-179.

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